Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 154
interventional 119
Observational 33
Registry 2

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 42
Drug|placebo 17
Device 14
Other 8
Procedure 8
Biological 6
Device|Drug 4
Drug|Procedure 4
Behavioral 2
Device|Other 2
Drug|Other 2
Behavioral|Other 1
Biological|placebo 1
Combination Product 1
Combination Product|Device 1
Combination Product|placebo 1
Device|Procedure 1
Dietary Supplement 1
Dietary Supplement|placebo 1
Dietary Supplement|placebo|Procedure 1
Other|placebo 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 51
NA 11
Canada 6
Finland 5
Spain 5
Israel 4
Australia 3
Czech Republic 2
Germany 2
Sweden 2
United States|Canada 2
American Samoa 1
Argentina|Colombia|Panama 1
Belgium 1
Brazil 1
China 1
Costa Rica 1
Costa Rica|Israel 1
Czechia 1
France 1
Germany|Poland 1
Greece 1
Greenland 1
Iran, Islamic Republic of 1
Italy 1
Italy|United Kingdom 1
Japan 1
Korea, Republic of 1
Nepal 1
Netherlands 1
Norway 1
Singapore 1
Slovenia 1
United Kingdom 1
United States|Argentina|Chile|Costa Rica|Dominican Republic|Estonia|Guatemala|Israel|Mexico|Panama|Poland|Russian Federation|Slovakia| 1
United States|Argentina|Chile|Costa Rica|Dominican Republic|Guatemala|Panama 1
United States|Chile|Costa Rica|Dominican Republic|Guatemala|Israel|Panama 1

Sites per Study

Site_count Study_Count
1 75
2 16
3 4
4 3
5 2
6 1
7 3
8 1
10 2
11 1
15 2
19 1
20 1
21 1
22 2
29 1
30 1
32 1
48 1

Phase

Phase Study_Count
N/A 40
Phase 3 40
Phase 2 17
Phase 4 12
Phase 1 4
Phase 1/Phase 2 3
Phase 2/Phase 3 2
Early Phase 1 1

Number of Arms

Number_of_Arms Count_of_Studies
1 18
2 65
3 16
4 8
5 1
NA 11

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 113 16.000 14.00 100.0000 25.000 53.0 56.000 65.0000
1st Qu. 113 40.750 21.50 126.5000 38.750 151.5 160.500 100.5000
Median 113 109.000 28.50 153.0000 69.500 250.0 304.000 150.0000
Mean 113 164.975 27.75 184.3333 96.375 250.0 2618.769 204.1667
3rd Qu. 113 212.250 34.75 226.5000 100.750 348.5 678.500 307.5000
Max. 113 1000.000 40.00 300.0000 328.000 447.0 55779.000 425.0000

Trial Group Type

group_type Group_Count
Experimental 98
Active Comparator 72
Placebo Comparator 27
Other 17
No Intervention 13
NA 11
Sham Comparator 6

Intervention Model

intervention_model Study_Count
Parallel Assignment 87
Single Group Assignment 23
NA 4
Crossover Assignment 2
Factorial Assignment 2
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 79
Prevention 17
Diagnostic 6
Other 6
Health Services Research 5
Supportive Care 3
Basic Science 2
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 11
NA 4
France 3
Germany 2
Turkey 2
Belgium 1
Canada 1
Colombia 1
Costa Rica 1
Denmark 1
Estonia|Lithuania|Poland|Romania|Slovenia 1
Israel 1
Panama 1
Saudi Arabia 1
South Africa 1
Sweden 1

Sites per Study

Site_count Study_Count
1 25
2 1
3 1
4 1
7 1
8 1
13 1
25 1
35 1

Enrollment Metrics

Measure Observational
Min 1.0000
1st Qu 52.0000
Median 140.0000
Mean 510.3636
3rd Qu 387.0000
Max 3293.0000

Observation Model

observational_model Study_Count
Cohort 16
Case-Only 4
Other 4
Case-Control 2
Case Control 2
Family-Based 2
Case-Crossover 1
Ecologic or Community 1
NA 1

Time Perspective

time_perspective Study_Count
Prospective 22
Cross-Sectional 5
Retrospective 5
NA 1

Registries

Studies by Country

Country Study_Count
Turkey 2

Sites per Study

Site_count Study_Count
1 2

Enrollment Metrics

Measure Registries
Min 33.0
1st Qu 43.5
Median 54.0
Mean 54.0
3rd Qu 64.5
Max 75.0

Registry Model

observational_model Study_Count
Case-Control 1
Case-Only 1

Time Perspective

time_perspective Study_Count
Prospective 2

Follow-up

target_duration Study_Count
1 Day 1
2 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT02801370 Phase 3 Study of OTO-201 in Acute Otitis Externa https://ClinicalTrials.gov/show/NCT02801370 Completed Otonomy, Inc. 2016-11-30
NCT02616458 The Impact of Ear Pain Anticipatory Guidance Counseling on Otitis Related Visits in a Low Income Population https://ClinicalTrials.gov/show/NCT02616458 Completed University of Colorado, Denver 2011-10-31
NCT02044341 Phase 3 Study to Compare the Efficacy and Safety of AR01 to a Placebo Solution for Relief of Pain in Acute Otitis Media https://ClinicalTrials.gov/show/NCT02044341 Completed Arbor Pharmaceuticals, Inc. 2014-03-31
NCT01535599 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa https://ClinicalTrials.gov/show/NCT01535599 Completed Alcon Research 2013-05-31
NCT03323736 In-Office Tympanostomy Tube Placement in Children (OTTER) https://ClinicalTrials.gov/show/NCT03323736 Active, not recruiting Tusker Medical 2019-02-28
NCT03277820 Effect of Probiotics on Nasopharyngeal Microbiome of Children With Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT03277820 Recruiting University Hospital, Antwerp 2020-12-30
NCT03197558 Adult Study to Evaluate Placement of Tympanostomy Tubes In-office (ADEPT) https://ClinicalTrials.gov/show/NCT03197558 Completed Tusker Medical 2017-09-14
NCT03196973 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa https://ClinicalTrials.gov/show/NCT03196973 Completed Salvat 2018-08-31
NCT03116737 Phase III Study Evaluating Topical Benzocaine for Treatment of Acute Otitis Media in Children https://ClinicalTrials.gov/show/NCT03116737 Completed Lachlan Pharma Holdings 2017-07-21
NCT03101605 E-learning on the Trainees’ Ability to Diagnose and Treat Acute Otitis Media Among Children https://ClinicalTrials.gov/show/NCT03101605 Completed St. Justine’s Hospital 2018-11-30
NCT03055091 Xylitol for the Prevention of Acute Otitis Media Episodes in Children https://ClinicalTrials.gov/show/NCT03055091 Recruiting St. Michael’s Hospital, Toronto 2021-06-30
NCT02935374 Effect of Antimicrobial Treatment of Acute Otitis Media on the Intestinal Microbiome in Children https://ClinicalTrials.gov/show/NCT02935374 Recruiting University of Oulu 2020-03-31
NCT02918773 Pediatric Emergency Department Smartphone Otoscope Study (PED-Oto) https://ClinicalTrials.gov/show/NCT02918773 Completed Emory University 2017-04-15
NCT02872558 Shared Decision Making in Parents of Children With Acute Otitis Media https://ClinicalTrials.gov/show/NCT02872558 Recruiting Mayo Clinic 2020-12-31
NCT02831985 Postoperative Controls of Ventilation Tubes in Children - by General Practitioner or Otolaryngologist? https://ClinicalTrials.gov/show/NCT02831985 Recruiting Norwegian University of Science and Technology 2021-04-30
NCT02817347 A Clinical Trial of YH1177 in Patients With Otitis Media and Otorrhea https://ClinicalTrials.gov/show/NCT02817347 Active, not recruiting Yuhan Corporation 2020-12-31
NCT02788422 Video Discharge Instructions for Acute Otitis Media https://ClinicalTrials.gov/show/NCT02788422 Completed Lawson Health Research Institute 2018-03-17
NCT01443416 An Alternative Booster Vaccine Against Meningitis and Ear Infections https://ClinicalTrials.gov/show/NCT01443416 Completed University of Oxford 2013-08-31
NCT02723890 The Efficacy and Safety of Using the Novel Tyto Device https://ClinicalTrials.gov/show/NCT02723890 Completed Rabin Medical Center 2017-01-31
NCT02719158 Dose Ranging Study of OTO-201 in AOMT https://ClinicalTrials.gov/show/NCT02719158 Completed Otonomy, Inc. 2016-06-30
NCT02630992 Reduced Clavulanate Formulation of Amoxicillin-Clavulanate in Children 6-23 Months With Acute Otitis Media https://ClinicalTrials.gov/show/NCT02630992 Completed University of Pittsburgh 2016-12-31
NCT02600559 Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes https://ClinicalTrials.gov/show/NCT02600559 Completed Otonomy, Inc. 2016-07-31
NCT02037893 Four Arm Safety & Efficacy With Antipyrine and Benzocaine Otic Solution in Children With Acute Otitis Media https://ClinicalTrials.gov/show/NCT02037893 Completed Currax Pharmaceuticals 2014-09-30
NCT02541760 Monteleukast Versus Inhaled Mometasone for Treatment of Otitis Media With Effusion in Children https://ClinicalTrials.gov/show/NCT02541760 Completed Hormozgan University of Medical Sciences 2015-03-31
NCT02539654 Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT) https://ClinicalTrials.gov/show/NCT02539654 Completed Alcon Research 2016-06-24
NCT02521597 Mobile Otoscopy - Efficacy of Residents to Diagnose Acute Otitis Media Using a Smartphone Otoscope Attachment https://ClinicalTrials.gov/show/NCT02521597 Completed St. Justine’s Hospital 2016-06-30
NCT02511561 OTO-201 for the Treatment of Otitis Externa https://ClinicalTrials.gov/show/NCT02511561 Completed Otonomy, Inc. 2015-11-30
NCT02452164 Family MobilePhone Otoscopy in Diagnostics of Otitis Media https://ClinicalTrials.gov/show/NCT02452164 Completed Turku University Hospital 2016-04-30
NCT02432105 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) https://ClinicalTrials.gov/show/NCT02432105 Completed Alcon Research 2016-06-15
NCT02436304 Safety and Efficacy of EXE844 Otic Suspension in Otitis Media at Time of Tympanostomy Tube Insertion (OMTT) - Study 2 https://ClinicalTrials.gov/show/NCT02436304 Completed Alcon Research 2016-08-04
NCT02408796 Open-Label Study of OTO-201 for Treatment of AOMT https://ClinicalTrials.gov/show/NCT02408796 Completed Otonomy, Inc. 2015-05-31
NCT02345447 Herbal-Based Medication vs. Placebo in Preventing Acute Otitis Media in Children at High Risk of Recurrence https://ClinicalTrials.gov/show/NCT02345447 Completed University Hospital Tuebingen 2015-10-31
NCT02183974 Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT02183974 Completed University Hospital Ostrava 2014-03-31
NCT02183961 Three Methods Used in the Diagnosis of EER in Children With OME https://ClinicalTrials.gov/show/NCT02183961 Completed University Hospital Ostrava 2014-03-31
NCT02165384 Hummingbird TTS Ear Tube Delivery Study https://ClinicalTrials.gov/show/NCT02165384 Completed Preceptis Medical, Inc. 2018-03-01
NCT02150044 Acclarent Tympanostomy Tube Delivery System for the Treatment of Patients Requiring Tympanostomy Tube Insertion https://ClinicalTrials.gov/show/NCT02150044 Completed Acclarent 2010-10-31
NCT02092454 Study to Assess the Safety and Efficacy of Benzocaine for Pain Relief in Children Presenting With Acute Otitis Media https://ClinicalTrials.gov/show/NCT02092454 Completed Otic Therapy, LLC 2014-03-31
NCT01312038 Effect of Simethicone on Eustachian Tube Dysfunction https://ClinicalTrials.gov/show/NCT01312038 Completed University of Pittsburgh 2014-07-31
NCT01949155 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement https://ClinicalTrials.gov/show/NCT01949155 Completed Otonomy, Inc. 2014-05-31
NCT01949142 OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement https://ClinicalTrials.gov/show/NCT01949142 Completed Otonomy, Inc. 2014-05-31
NCT01588535 Study of FAECC Scale (Modified FLACC) to Evaluate Ear Pain in Children With Acute Otitis Media https://ClinicalTrials.gov/show/NCT01588535 Completed Arbor Pharmaceuticals, Inc. 2012-08-31
NCT01535560 Safety and Efficacy Evaluation of Topical AL-60371 Otic Suspension, 0.3% in the Treatment of Acute Otitis Externa https://ClinicalTrials.gov/show/NCT01535560 Completed Alcon Research 2012-10-31
NCT01535131 Furlow Palatoplasty With Tensor Tenopexy https://ClinicalTrials.gov/show/NCT01535131 Active, not recruiting University of Pittsburgh 2019-12-31
NCT01447017 A Study of DPK-060 to Investigate Clinical Safety and Efficacy in Patients With Acute External Otitis https://ClinicalTrials.gov/show/NCT01447017 Completed DermaGen AB 2012-10-31
NCT01404611 Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients https://ClinicalTrials.gov/show/NCT01404611 Completed Salvat 2013-05-31
NCT01395966 Clinical Study to Assess the Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Middle Ear Infections in Pediatric Patients https://ClinicalTrials.gov/show/NCT01395966 Completed Salvat 2014-06-30
NCT01359098 Efficacy and Safety of Once-Daily Ciprodexa Otic Foam Compared to Twice-daily Ciprodex Ear Drops in Acute Otitis Externa https://ClinicalTrials.gov/show/NCT01359098 Completed Otic Pharma 2011-10-31
NCT04296448 Evaluation of Cellphone Based Otoscopy in Pediatric Patients https://ClinicalTrials.gov/show/NCT04296448 Completed Johns Hopkins University 2020-03-01
NCT04281901 Efficacy of Platelet- and Extracellular Vesicle-rich Plasma in Chronic Postsurgical Temporal Bone Inflammations https://ClinicalTrials.gov/show/NCT04281901 Active, not recruiting University Medical Centre Ljubljana 2020-06-30
NCT04219553 Antimicrobial Stewardship in Community Pharmacy https://ClinicalTrials.gov/show/NCT04219553 Completed University of Toronto 2017-11-15
NCT03916029 Hearing for Learning Initiative - a Health Facilitator Model for Otitis Media https://ClinicalTrials.gov/show/NCT03916029 Recruiting Menzies School of Health Research 2022-12-31
NCT03818815 A Study to Assess the Safety, Tolerability and Efficacy of OP0201 as an Adjunct Treatment for Acute Otitis Media in Infants and Children Aged 6 to 24 Months https://ClinicalTrials.gov/show/NCT03818815 Active, not recruiting Novus Therapeutics, Inc 2020-03-31
NCT03766373 Evaluation of Safety and Reduction of Ear Pain in Adults With Acute Otitis Media and Reduction of Ear Pain in Adults With Acute Otitis Media https://ClinicalTrials.gov/show/NCT03766373 Completed Novus Therapeutics, Inc 2019-01-30
NCT03722160 Clinical Study of the Solo Tympanostomy Tube Device https://ClinicalTrials.gov/show/NCT03722160 Recruiting AventaMed DAC 2019-11-30
NCT03675841 Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media https://ClinicalTrials.gov/show/NCT03675841 Recruiting Lee’s Pharmaceutical Limited 2019-01-30
NCT03614117 Effect of a New Probiotic Strain on Recurrent Acute Otitis Media in Children (PROMAR) https://ClinicalTrials.gov/show/NCT03614117 Active, not recruiting ProbiSearch SL 2020-06-30
NCT03590912 Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT03590912 Completed Lumbini Medical College 2020-02-16
NCT03556215 Balloon Eustachian Tuboplasty in Treatment of Chronic Eustachian Tube Dysfunction https://ClinicalTrials.gov/show/NCT03556215 Recruiting University Hospital Ostrava 2020-05-31
NCT03544138 Pivotal Clinic Study of the H-TTS https://ClinicalTrials.gov/show/NCT03544138 Recruiting Preceptis Medical, Inc. 2020-08-31
NCT03534219 Efficacy of the EarPopper Device in Children With Recurrent Otitis Media https://ClinicalTrials.gov/show/NCT03534219 Recruiting Northwell Health 2019-12-01
NCT01263210 Pneumococcal Vaccination of Otitis-prone Children https://ClinicalTrials.gov/show/NCT01263210 Completed Lund University Hospital 2009-06-30
NCT01244581 Amoxicillin-clavulanate in Treating Acute Otitis Media Evaluated by Daily Tympanometry https://ClinicalTrials.gov/show/NCT01244581 Completed University of Oulu 2012-06-30
NCT01244126 Postoperative Effects of Intranasal Fentanyl, IV and IM Morphine in Children Undergoing Myringotomy https://ClinicalTrials.gov/show/NCT01244126 Completed Baylor College of Medicine 2011-05-31
NCT01202578 Evaluation of the Tympanostomy Tube Delivery System https://ClinicalTrials.gov/show/NCT01202578 Completed Acclarent 2010-11-30
NCT01174849 Pneumococcal Vaccines Early and in Combination https://ClinicalTrials.gov/show/NCT01174849 Completed Menzies School of Health Research 2017-09-21
NCT00279916 Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays https://ClinicalTrials.gov/show/NCT00279916 Completed Mayo Clinic 2009-02-28
NCT01157819 Safety and Efficacy of Once-Daily Dosing of FoamOtic Cipro Compared to Twice-Daily Dosing of Ciloxan Ear Drops in Patients With Acute External Otitis https://ClinicalTrials.gov/show/NCT01157819 Completed Otic Pharma 2010-11-30
NCT01082029 Study of Anti-reflux Medication as a Potential Treatment for Glue Ear in Children https://ClinicalTrials.gov/show/NCT01082029 Completed McMaster University 2014-06-30
NCT01046877 Singapore Tympanostomy Tube Delivery System Study https://ClinicalTrials.gov/show/NCT01046877 Completed Acclarent 2010-08-31
NCT01044030 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children https://ClinicalTrials.gov/show/NCT01044030 Completed Boston Children’s Hospital 2012-06-30
NCT01033799 Effect of the Consumption of a Fermented Milk on Common Infections in Shift-workers https://ClinicalTrials.gov/show/NCT01033799 Completed Danone Research 2007-04-30
NCT01022944 Prevalence of Mucosal Biofilm Formations in Adenoidectomy Specimens https://ClinicalTrials.gov/show/NCT01022944 Completed Assistance Publique - Hôpitaux de Paris 2012-05-31
NCT01003210 Homeopathic Ear Drops for Otitis Media Study https://ClinicalTrials.gov/show/NCT01003210 Completed University of Washington 2013-04-30
NCT00961675 FST-201 in the Treatment of Acute Otitis Externa https://ClinicalTrials.gov/show/NCT00961675 Completed Shire 2010-06-30
NCT00941993 Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus https://ClinicalTrials.gov/show/NCT00941993 Completed Acclarent 2011-01-31
NCT00939796 Clinical Study of the Tympanostomy Tube Delivery System https://ClinicalTrials.gov/show/NCT00939796 Completed Acclarent 2009-06-30
NCT00872209 Safety and Efficacy Study of Foam Otic Cipro Compared to a Standard Solution ( Ciloxan - Alcon Labs ) to Treat Acute Otitis Externa https://ClinicalTrials.gov/show/NCT00872209 Completed Otic Pharma 2009-10-31
NCT00980876 A Comparative Study Between Two Formulations of the Ciprofloxacin Hydrochloride + Hydrocortisone Otic Suspension https://ClinicalTrials.gov/show/NCT00980876 Completed Farmoquimica S.A. 2015-01-31
NCT00839254 Impact on Carriage, Acute Otitis Media, Immuno & Safety of GSK Biologicals’ Pneumococcal Conjugate Vaccine 1024850A https://ClinicalTrials.gov/show/NCT00839254 Completed GlaxoSmithKline 2012-01-31
NCT02858388 Sinuclean Nebules 45 for Treatment of Pediatric Exudative Otitis Media https://ClinicalTrials.gov/show/NCT02858388 Completed Galsor S.r.l. 2015-09-30
NCT02490332 The Effects of Ventilation Tubes - The SIUTIT Trial https://ClinicalTrials.gov/show/NCT02490332 Recruiting Zealand University Hospital 2020-08-31
NCT02610699 Community Pediatric Acceptability Study (CPAS) https://ClinicalTrials.gov/show/NCT02610699 Completed Emory University 2015-06-30
NCT02567825 Efficacy of Tympanostomy Tubes for Children With Recurrent Acute Otitis Media https://ClinicalTrials.gov/show/NCT02567825 Active, not recruiting University of Pittsburgh 2020-03-31
NCT04016051 Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections https://ClinicalTrials.gov/show/NCT04016051 Completed Grünenthal GmbH 2004-12-23
NCT00781521 Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children https://ClinicalTrials.gov/show/NCT00781521 Completed Daiichi Sankyo, Inc. 2003-04-30
NCT00765635 Chlorobutanol, Potassium Carbonate, and Irrigation in Cerumen Removal https://ClinicalTrials.gov/show/NCT00765635 Completed Hospital Clinic of Barcelona 2008-10-31
NCT00750633 A Phase III Study of an Otic Formulation in Acute Otitis Externa https://ClinicalTrials.gov/show/NCT00750633 Completed Alcon Research 2009-01-31
NCT00654329 Dexmedetomidine vs Fentanyl for BMT https://ClinicalTrials.gov/show/NCT00654329 Completed Children’s National Research Institute 2008-12-31
NCT00644943 A Comparison of the Safety and Efficacy of Cefdinir Oral Suspension Versus Amoxicillin/Clavulanate in Pediatric Subjects With Acute Otitis Media https://ClinicalTrials.gov/show/NCT00644943 Completed Abbott 2003-04-30
NCT00643292 A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections https://ClinicalTrials.gov/show/NCT00643292 Completed Pfizer NA
NCT00638534 Japanese Study Evaluating the Effects of Telithromycin in Children With Acute Otitis Media https://ClinicalTrials.gov/show/NCT00638534 Completed Sanofi 2004-10-31
NCT00617682 Maternal Immunization To Prevent Infant Otitis Media https://ClinicalTrials.gov/show/NCT00617682 Completed National Institute on Deafness and Other Communication Disorders (NIDCD) 2004-12-31
NCT00629694 Adenoidectomy, Myringotomy and Tubes’ Insertion vs Adenoidectomy and Myringotomy Alone in Children With Otitis Media With Effusion and Adenoid Hypertrophy https://ClinicalTrials.gov/show/NCT00629694 Completed Aghia Sophia Children’s Hospital of Athens 2009-05-31
NCT00622518 Ear Drops for Children With Otitis Media https://ClinicalTrials.gov/show/NCT00622518 Completed University of Washington 2009-02-28
NCT00581711 Improving Otitis Media Care With Clinical Decision Support https://ClinicalTrials.gov/show/NCT00581711 Completed Children’s Hospital of Philadelphia 2010-09-30
NCT00579189 Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes https://ClinicalTrials.gov/show/NCT00579189 Completed Alcon Research 2009-01-31
NCT00578773 A Phase II Study of an Otic Formulation in Treating Peri-Operative Tube Otorrhea https://ClinicalTrials.gov/show/NCT00578773 Completed Alcon Research 2009-01-31
NCT00578474 A Phase III Study of an Otic Formulation in Acute Otitis Media With Tympanostomy Tubes https://ClinicalTrials.gov/show/NCT00578474 Completed Alcon Research 2008-08-31
NCT00546117 A Clinical Trial of Proton Pump Inhibitors to Treat Children With Chronic Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT00546117 Completed Washington University School of Medicine 2009-12-31
NCT00539149 Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children https://ClinicalTrials.gov/show/NCT00539149 Completed Menzies School of Health Research NA
NCT00520039 Osteopathic Otitis Media Research Study https://ClinicalTrials.gov/show/NCT00520039 Completed West Virginia School of Osteopathic Medicine 2009-08-31
NCT00466947 COMPAS (Clinical Otitis Media & Pneumonia Study): Pneumonia & Acute Otitis Media (AOM ) Efficacy Study of the Pneumococcal Conjugate Vaccine https://ClinicalTrials.gov/show/NCT00466947 Completed GlaxoSmithKline 2010-08-31
NCT00378417 Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes https://ClinicalTrials.gov/show/NCT00378417 Completed National Institute for Health and Welfare, Finland NA
NCT00377260 Acute Otitis Media (AOM) Therapy Trial in Young Children https://ClinicalTrials.gov/show/NCT00377260 Completed University of Pittsburgh 2009-04-30
NCT00365092 Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11 https://ClinicalTrials.gov/show/NCT00365092 Completed Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) NA
NCT00360100 Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media https://ClinicalTrials.gov/show/NCT00360100 Completed Pfizer NA
NCT00276042 A Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media https://ClinicalTrials.gov/show/NCT00276042 Completed Replidyne 2007-01-31
NCT00250900 Wait and See Antibiotic Prescription for Acute Otitis Media: A Randomized Controlled Trial https://ClinicalTrials.gov/show/NCT00250900 Completed Yale University NA
NCT00189462 A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children https://ClinicalTrials.gov/show/NCT00189462 Completed West Penn Allegheny Health System 2005-12-31
NCT00189098 Effectiveness of Sulfamethoxazole-trimethoprim in the Treatment of Chronic Otitis Media https://ClinicalTrials.gov/show/NCT00189098 Completed UMC Utrecht 2006-06-30
NCT00001605 Vaccination for Middle Ear Infection https://ClinicalTrials.gov/show/NCT00001605 Completed National Institutes of Health Clinical Center (CC) NA
NCT00010465 Nervous System Manipulation and Botanicals for the Treatment of Recurrent Ear Infections in Children https://ClinicalTrials.gov/show/NCT00010465 Completed National Center for Complementary and Integrative Health (NCCIH) 2002-12-31
NCT00044473 A Study of the Effectiness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat https://ClinicalTrials.gov/show/NCT00044473 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00796224 Pharmacokinetics Of Azithromycin Immediate Release And Extended Release Formulation In Kids With Acute Otitis Media https://ClinicalTrials.gov/show/NCT00796224 Completed Pfizer 2009-02-28
NCT00689468 Echinacea Purpurea and Osteopathy in Children With Recurrent Otitis Media https://ClinicalTrials.gov/show/NCT00689468 Completed University of Arizona 2002-09-30
NCT00645112 A Comparison of Safety and Efficacy of Cefdinir Oral Suspension Versus Azithromycin in Pediatric Subjects With Acute Otitis Media https://ClinicalTrials.gov/show/NCT00645112 Completed Abbott 2004-01-31
NCT00645203 Safety and Efficacy Study of Cefdinir Oral Suspension, in Pediatric Subjects to Treat Acute Otitis Media https://ClinicalTrials.gov/show/NCT00645203 Completed Abbott 2003-04-30
NCT00051753 Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media https://ClinicalTrials.gov/show/NCT00051753 Completed Johnson & Johnson Pharmaceutical Research & Development, L.L.C. NA
NCT00000363 Acute Otitis Media: Adjuvant Therapy to Improve Outcome https://ClinicalTrials.gov/show/NCT00000363 Completed National Institute on Deafness and Other Communication Disorders (NIDCD) NA

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT03109496 The URT and Middle Ear Microbiota in Health and During Chronic OME https://ClinicalTrials.gov/show/NCT03109496 Completed University Hospital, Antwerp 2019-06-06
NCT02591563 Evaluate Pathogens and Immunity to Acute Otitis Media in Healthy Children. https://ClinicalTrials.gov/show/NCT02591563 Recruiting Rochester General Hospital 2025-12-31
NCT02567747 Vaccination Impact Against Pneumococcal Disease on Acute Otitis Media Morbidity in Colombian Children < 5 Years of Age https://ClinicalTrials.gov/show/NCT02567747 Completed GlaxoSmithKline 2018-02-01
NCT02179541 A Novel Objective Diagnostic Test for Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT02179541 Completed Bezmialem Vakif University 2013-05-31
NCT02096848 Microbiology of Otitis Media in Costarrican Children After PCV13 Introduction https://ClinicalTrials.gov/show/NCT02096848 Completed Instituto de Atención Pediátrica 2014-03-31
NCT01272999 Impact of Prevnar 13 on Ear Infections in Children https://ClinicalTrials.gov/show/NCT01272999 Completed Pfizer 2013-12-31
NCT01941381 Does Tympanometry Predict Antibiotic Usage in Acute Otitis Media? https://ClinicalTrials.gov/show/NCT01941381 Completed University of Alberta 2018-09-30
NCT01793857 Healthcare Seeking Behaviour of Primary Caregivers for Acute Otitis Media (AOM) in Children Aged 6 Months to Less Than 30 Months in Panama https://ClinicalTrials.gov/show/NCT01793857 Completed GlaxoSmithKline 2013-05-31
NCT02558738 Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal Irritations https://ClinicalTrials.gov/show/NCT02558738 Completed Bitop AG 2015-08-31
NCT01406275 Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media) https://ClinicalTrials.gov/show/NCT01406275 Completed GlaxoSmithKline 2008-12-31
NCT01365390 To Evaluate the Incidence of Acute Otitis Media in Children in Five East European Countries https://ClinicalTrials.gov/show/NCT01365390 Completed GlaxoSmithKline 2012-12-31
NCT01339546 National Trends in Otitis Media in Children Under 5 Years of Age https://ClinicalTrials.gov/show/NCT01339546 Completed Pfizer 2017-06-30
NCT04395261 Wideband Tympanometry in Otitis Media With Effusion https://ClinicalTrials.gov/show/NCT04395261 Completed Pamukkale University 2018-12-30
NCT03975842 Chronic Otitis Media With Effusion in Chronic Sinusitis With Polyps https://ClinicalTrials.gov/show/NCT03975842 Completed Fondation Ophtalmologique Adolphe de Rothschild 2012-12-31
NCT00195611 Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media https://ClinicalTrials.gov/show/NCT00195611 Completed Wyeth is now a wholly owned subsidiary of Pfizer 2006-06-30
NCT03890107 Clinical Evaluation of the TOMi Scope https://ClinicalTrials.gov/show/NCT03890107 Recruiting PhotoniCare, Inc. 2020-06-30
NCT03864055 Otogenic CSVT Retrospective Case Series and Associated Thrombophilia https://ClinicalTrials.gov/show/NCT03864055 Completed HaEmek Medical Center, Israel 2019-02-03
NCT03768635 Necrotizing External Otitis : Study in a Regional Bone and Joint Infection Reference Center https://ClinicalTrials.gov/show/NCT03768635 Completed Hospices Civils de Lyon 2018-01-31
NCT03715569 CNS Infections Effect on the Inner Ear https://ClinicalTrials.gov/show/NCT03715569 Recruiting Nordsjaellands Hospital 2020-12-01
NCT03611842 Study of the Expression of MMPs in OME in Children With Atrophy of the Eardrum https://ClinicalTrials.gov/show/NCT03611842 Completed University Hospital, Montpellier 2018-11-01
NCT03503591 Study of the Hummingbird TTSâ„¢ Tympanostomy Tube System https://ClinicalTrials.gov/show/NCT03503591 Recruiting Preceptis Medical, Inc. 2020-08-31
NCT01251432 Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults https://ClinicalTrials.gov/show/NCT01251432 Completed University of Pittsburgh 2016-05-31
NCT01204385 Study to Identify and Characterize the Bacteria Causing Acute Otitis Media Episodes in Young Children in Saudi Arabia https://ClinicalTrials.gov/show/NCT01204385 Completed GlaxoSmithKline 2011-05-31
NCT01199016 Effect of Prevnar 13 on Ear Infections in Children https://ClinicalTrials.gov/show/NCT01199016 Completed Pfizer 2016-01-31
NCT01031082 Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children https://ClinicalTrials.gov/show/NCT01031082 Completed GlaxoSmithKline 2010-05-31
NCT01027494 Topical Treatment of Acute Otitis Media Through Tympanostomy Tubes (AOMT) and Its Effect on Microbial Flora https://ClinicalTrials.gov/show/NCT01027494 Completed Alcon Research 2012-11-30
NCT04396145 The Effects of Chronic Otitis Surgery on SVV https://ClinicalTrials.gov/show/NCT04396145 Recruiting Pamukkale University 2020-12-30
NCT02742753 Impact of Pneumococcal Conjugate Vaccines on Otitis Media and Acute Otitis Media in Swedish Children https://ClinicalTrials.gov/show/NCT02742753 Completed GlaxoSmithKline 2017-05-18
NCT00768534 Study Evaluating Microbiological Analysis of Spontaneous Draining Acute Otitis Media https://ClinicalTrials.gov/show/NCT00768534 Completed Pfizer 2015-10-31
NCT00694486 Eustachian Tube Testing in a Pressure Chamber – Validation Study https://ClinicalTrials.gov/show/NCT00694486 Completed University of Pittsburgh 2010-07-31
NCT00422929 Eustachian Tube Growth and Development https://ClinicalTrials.gov/show/NCT00422929 Completed University of Pittsburgh 2017-01-16
NCT00422136 Genetics of Middle Ear Disease https://ClinicalTrials.gov/show/NCT00422136 Completed University of Pittsburgh 2007-07-31
NCT00393900 Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion https://ClinicalTrials.gov/show/NCT00393900 Completed University of Pittsburgh 2012-10-31

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03848026 Tympanostomy Tube Extrusion Time & Viscosity https://ClinicalTrials.gov/show/NCT03848026 Completed Bezmialem Vakif University 2019-06-15
NCT03954288 The Serum Sclerostin Levels in Cholesteatoma Patients https://ClinicalTrials.gov/show/NCT03954288 Recruiting Abant Izzet Baysal University 2020-02-15